Research Projects
Evaluation of WAning Vaccine Effectiveness (WAVE)
Information regarding decreasing VE is essential to optimally design booster vaccination campaigns with respect to the risk of outbreaks and whether repeated vaccination is cost-effective and ethical. The COVID-19 pandemic highlighted the lack of robust methods to: assess waning vaccine effectiveness, disentangle true from perceived waning, and identify determinants of waning. In this project, we aim to develop and rigorously compare methods to assess waning vaccine-induced protection (for vaccines such as those against pertussis, influenza, and COVID-19). Using these methods, we will analyze data from observational studies to estimate the rate of waning vaccine effectiveness and determine how individual characteristics influence rate of waning vaccine-induced protection.
Modelling the impact of vaccination strategies
In this project, we use mathematical models of infectious disease transmission to determine the impact of vaccination strategies on disease spread. Specifically, we developed a deterministic age-structured compartmental model to compare different COVID-19 vaccination scenarios with respect to disease outcomes (e.g., infections, hospitalisations). This work also contributed to the European Scenario Modelling Hub.